Bioorganic Chemistry Group

Contact

Research

Our interdisciplinary research at the interface of Chemistry, Biology, and Medicine (Life Sciences) focuses on the use of peptides as tools for the investigation of biological and (patho-)physiological processes on molecular level. For this purpose, the organic synthesis of oligo- and polypeptides up to miniproteins is realized by means of solid-phase peptide synthesis (SPPS). The synthesis products are then purified and chemically characterized using bioanalytical methods. Protein/peptide-ligand interactions are analyzed using biophysical techniques and structure-function relationships using clinical diagnostic methods. A particular focus of our work is the investigation of heme-protein interactions in the context of the development of hemolysis-associated coagulation disorders as well as the analysis of amphibian secretions.

Heme/Thrombosis Research

Amphibian Secretion Research

Methods

Research infrastructure

This research is part of the Life Science research at the University of Koblenz. Disciplines, in which we take part, are highlighted in green. © M. Hopp

Our group is a member of the interdisciplinary Institute for Medical Technology and Information Processing Mittelrhein (MTI).

Teaching

Research projects and theses can be performed in the research area of the working group by arrangement. Current calls for applications can be found here.

If you are interested, please contact Jun.-Prof. Dr. Hopp directly (mhopp(at)uni-koblenz.de).

Current Courses

We support the youth science competition "Jugend forscht". Submit your research project until 11/30/2024! More information can be found here.

News

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Projects

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Publications

Kröner, L., Lötters, S., Hopp, M.-T. (2024) Insights into caudate amphibian skin secretions with a focus on the chemistry and bioactivity of derived peptides. Biol. Chem., DOI: 10.1515/hsz-2024-0035

Hopp, M.-T.*, Ugurlar, D., Pezeshkpoor, B., Biswas, A., Ramoji, A., Neugebauer, U., Oldenburg, J., Imhof, D. (2024) In-depth structure-function profiling of the complex formation between coagulation factor VIII and heme. Thromb. Res. 237: 184-195.

Hopp, M.-T., Holze, J., Lauber, F., Holtkamp, L., Rathod, D. C., Miteva, M. A., Prestes, E. B., Geyer, M., Manoury, B., Merle, N., Roumenina, L., Bozza, M. T., Weindl, G., Imhof, D. (2024) Insights into the molecular basis and mechanism of heme-triggered TLR4 signaling: The role of heme-binding motifs in TLR4 and MD2. Immunology, doi: 171(2), 181-197.

Hopp, M.-T., Rathod, D. C., Imhof, D. (2022) Host and viral proteins involved in SARS-CoV-2 infection differentially bind heme. Protein Sci. 31(11), e4451.

Hopp, M.-T., Alhanafi, N., Paul George, A. A., Hamedani, N. S., Biswas, A., Oldenburg, J., Pötzsch, B., Imhof, D. (2021) Molecular insights and functional consequences of the interaction of heme with activated protein C. Antioxid. Redox. Signal. 34(1), 32-48.

All Publications