Isotope-labeled dicarboxylic acids and hydroxycarboxylic acids with reference to the biological polyesters cutin and suberin

Cutin and suberin are naturally occurring polyesters that form an outer barrier in plants between the plant and the surrounding atmosphere (cutin) or soil (suberin). Among other things, they therefore regulate the water balance of plants and provide protection against the penetration of plant pathogens. Each plant species has an individual pattern of components of these polyesters, which consist of fatty acids, long-chain dicarboxylic acids or hydroxycarboxylic acids, long-chain alkanols and alkanediols as well as glycerol. We selectively synthesize isotope-labeled (2H, 13C) derivatives in order to investigate the biochemical degradation pathways of these compounds together with cooperation partners.

Publications

Schink, C., Spielvogel, S., Imhof, W. (2021) Synthesis and characterization of ¹³C-labelled cutin and suberin monomeric dicarboxylic acids of the general formula HO₂¹³C-(CH₂)_n-¹³CO₂H (n = 10, 12, 14, 16, 18, 20, 22, 24, 26, 28). J. Label. Compd. Radiopharm. 64, 14.

Schink, C., Spielvogel, S., Imhof, W. (2021) Synthesis ¹³C-labelled ω-hydroxy carboxylic acids of the general formula HO₂¹³C-(CH₂)_n-CH₂OH or HO₂C-(CH₂)_n-¹³CH₂OH (n = 12, 16, 20, 28). J. Label. Compd. Radiopharm. 64, 385.

Kashi, H., Loeppmann, S., Herschbach, J., Schink, C., Imhof, W., Kouchaksaraee, R.M., Dippold, M.A., Spielvogel, S. (2022) Size matters: Biochemical mineralization and microbial incorporation of dicarboxylic acids in soil. Biogeochemistry 162, 79.